Fri Sep 30 2022

72 articles - From Friday Sep 23 2022 to Friday Sep 30 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Ann Intern Med

Cancer Screening Guidelines Are Not Simple, But They Could Be Less Complex.

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Evaluation of Harms Reporting in U.S. Cancer Screening Guidelines.

The review identified opportunities for improving conceptualization, assessment, and reporting of screening process-related harms in guidelines. Future work should consider nuances associated with each organ-specific process to screen for cancer, including which harms are most salient and where evidence gaps exist, and explicitly explore how to optimally weigh available evidence in determining net screening benefit. Improved harms reporting could aid informed decision making, ultimately improving cancer screening delivery. Primary funding source National Cancer Institute.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Adenoma Detection Rate and Risk for Interval Postcolonoscopy Colorectal Cancer in Fecal Immunochemical Test-Based Screening : A Population-Based Cohort Study.

The ADR of endoscopists is inversely associated with the risk for interval PCCRC in FIT-positive colonoscopies. Endoscopists performing colonoscopy in FIT-based screening should aim for markedly higher ADRs compared with primary colonoscopy. Primary funding source None.

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Benefits and Risks Associated With Continuation of Anti-Tumor Necrosis Factor After 24 Weeks of Pregnancy in Women With Inflammatory Bowel Disease : A Nationwide Emulation Trial.

Continuation of anti-TNF after 24 weeks of pregnancy appears beneficial regarding IBD activity and prematurity, while not affecting neonatal outcomes and serious infections in the offspring. Primary funding source None.

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Lancet

Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial.

From 12 months to 36 months after the procedure, patients who were originally randomly assigned to receive renal artery denervation had larger reductions in blood pressure and better blood pressure control compared with patients who received sham control. Funding Medtronic.

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Socioeconomic inequalities in cancer incidence and access to health services among children and adolescents in China: a cross-sectional study.

With regards to achieving the Sustainable Development Goals, policy approaches should prioritise increasing the accessibility of health services for early diagnosis to improve outcomes and subsequently reduce disease burdens, as well as narrowing the socioeconomic inequalities of childhood and adolescent cancer. Funding National Major Science and Technology Projects of China, National Natural Science Foundation of China, Chinese Academy of Engineering Consulting Research Project, Wu Jieping Medical Foundation, Beijing Municipal Administration of Hospitals Incubating Program.

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N Engl J Med

Glycemia Reduction in Type 2 Diabetes - Glycemic Outcomes.

All four medications, when added to metformin, decreased glycated hemoglobin levels. However, glargine and liraglutide were significantly, albeit modestly, more effective in achieving and maintaining target glycated hemoglobin levels. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; GRADE ClinicalTrials.gov number, NCT01794143.).

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Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes.

In participants with type 2 diabetes, the incidences of microvascular complications and death were not materially different among the four treatment groups. The findings indicated possible differences among the groups in the incidence of any cardiovascular disease. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; GRADE ClinicalTrials.gov number, NCT01794143.).

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GPRC5D-Targeted CAR T Cells for Myeloma.

The results of this study of a GPRC5D-targeted CAR T-cell therapy (MCARH109) confirm that GPRC5D is an active immunotherapeutic target in multiple myeloma. (Funded by Juno Therapeutics/Bristol Myers Squibb; ClinicalTrials.gov number, NCT04555551.).

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Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes.

In this 13-week, randomized trial involving adults and children with type 1 diabetes, use of a bionic pancreas was associated with a greater reduction than standard care in the glycated hemoglobin level. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; ClinicalTrials.gov number, NCT04200313.).

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Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.

(Funded by Biogen; VALOR and OLE ClinicalTrials. gov numbers, NCT02623699 and NCT03070119; EudraCT numbers, 2015-004098-33 and 2016-003225-41.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

Current best practice for bladder cancer: a narrative review of diagnostics and treatments.

We discuss the current role of radiotherapy, surgical management of non-muscle-invasive and muscle-invasive disease, highlight the challenges of treatment of metastatic bladder cancer, and discuss the latest developments in systemic therapy. This Seminar is intended to provide physicians with knowledge of current issues in bladder cancer.

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Has traditional medicine had its day? The need to redefine academic medicine.

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Offline: The scramble for science.

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N Engl J Med

After Metformin - Next Steps for Type 2 Diabetes with Low Cardiovascular Risk.

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Audio Interview: Assessing Bivalent Vaccines against Covid-19.

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Audio Interview: Can Vaccines Prevent Transmission of Covid-19?

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Burkitt's Lymphoma.

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Doubling Down on a Medical Medium.

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Gastroesophageal Reflux Disease.

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Seeking Simpler Solutions with Diabetes Technology.

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Treatment and Prevention of Heat-Related Illness.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Intern Med

Annals Graphic Medicine - Five Senses of Medicine.

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Developing Meaningful Health Care Quality Metrics: An Example From Colonoscopy and Adenoma Detection.

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Double-Blind.

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Lancet

Afghanistan's health system under the Taliban: key challenges.

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Chilling to the marrow: finding extramedullary haematopoiesis in an unusual location behind the xiphoid.

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Daniel Graymore.

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Digitising brain age.

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Global Influenza Surveillance and Response System: 70 years of responding to the expected and preparing for the unexpected.

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Health organisations call for non-proliferation of fossil fuels.

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Peter Waiswa: building better health systems in Africa and beyond.

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Safeguarding children's health in a changing global environment.

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SYMPLICITY HTN-3: failure at 6 months, success at 3 years?

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Uncertainty over the future of Sri Lankan health care.

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Using data to improve care: childhood cancer in China.

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War driving cholera in Syria.

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N Engl J Med

A Hidden Crisis.

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Autosomal Dominant Osteopetrosis.

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Case 29-2022: A 33-Year-Old Man with Chronic Diarrhea and Autoimmune Enteropathy.

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Case 30-2022: A Newborn Girl with Hypoglycemia.

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Circulating Cell-free DNA and Screening for Trisomies.

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Integrins in Health and Disease.

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Lepromatous Leprosy.

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Product Hopping in the Drug Industry - Lessons from Albuterol.

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Sickle Cell Disease and Gene Therapy - Patient and Physician Perspectives.

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The On- and Off-Ramps of Oncology Accelerated Approval.

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The War-Zone Mentality - Mental Health Effects of Gun Violence in U.S. Children and Adolescents.

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Transforming Management of Opioid Use Disorder with Universal Treatment.

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Wellens' Syndrome.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Characterising adults in Scotland who are not vaccinated against COVID-19.

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Evolutionary consequences of delaying intervention for monkeypox.

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Maintenance antipsychotic trials and the effect of withdrawal - Authors' reply.

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Maintenance antipsychotic trials and the effect of withdrawal.

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N Engl J Med

A Novel Circulating MicroRNA for the Detection of Acute Myocarditis.

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A Novel Circulating MicroRNA for the Detection of Acute Myocarditis. Reply.

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Adagrasib in Non-Small-Cell Lung Cancer.

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Adagrasib in Non-Small-Cell Lung Cancer. Reply.

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IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination.

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Pulmonary Embolism.

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Pulmonary Embolism.

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Pulmonary Embolism.

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Pulmonary Embolism.

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Pulmonary Embolism. Reply.

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Quality Improvement and Children's Hospitals.

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Trastuzumab Deruxtecan in HER2-Low Breast Cancer.

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Trastuzumab Deruxtecan in HER2-Low Breast Cancer.

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Trastuzumab Deruxtecan in HER2-Low Breast Cancer. Reply.

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Treatment of Mantle-Cell Lymphoma.

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Treatment of Mantle-Cell Lymphoma.

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Treatment of Mantle-Cell Lymphoma.

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Treatment of Mantle-Cell Lymphoma. Reply.

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